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KMID : 0984920170190020055
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Journal of Skin Barrier Research
2017 Volume.19 No. 2 p.55 ~ p.55
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Effects of rhEGF and Palmitoyl pentapeptide-4 for Skin Regeneration after Glycolic Acid Peeling
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Lim Bo-Ra
Park Kun
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Abstract
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Backgrounds: Glycolic acid peel is a popular superficial peeling technique associated with low morbidity and prompt recovery. These processes, as well as the final step of corneodesmolysis, which mediates exfoliation, are often disturbed by environmental conditions, resulting in dry, flaky skin conditions. Therefore, aftercare is required to avoid these side effects and achieve the maximum possible improvement in skin condition.
Objectives: To evaluate the skin regeneration effect of rhEGF and palmitoyl pentapeptide-4 after glycolic acid peeling.
Methods: A base gel, a gel containing rhEGF, and a gel containing palmitoyl pentapeptide-4 were prepared, and their safety was evaluated by patch test. The 30 healthy female volunteers (age: 25-39 years) underwent a glycolic acid (20%) face peel once per week and then the prepared gels were applied to the face for 4 weeks. Stratum corneum hydration, transepidermal water loss (TEWL), and erythema index were then evaluated.
Results: No specific skin reaction in prepared gels were detected by patch test. In the application group of rhEGF and palmitoyl pentapeptide-4, stratum corneum hydration is increased, TEWL and erythema index are reduced. Therefore, the skin regeneration effect was confirmed. The skin regeneration effect of palmitoyl pentapeptide-4 application group was shown to be the best result in particular.
Conclusions: The gels containing rhEGF and palmitoyl pentapeptide-4 were safe and effective for skin recovery after glycolic acid peeling. The palmitoyl pentapeptide-4-containing gel was superior to the rhEGF-containing gel in terms of skin regeneration after peeling.
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KEYWORD
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rhEGF, Palmitoyl pentapeptide-4, Skin Regeneration, Gel
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